Publications

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Journal Articles

  1. Chester, D., Kathard, R., Nortey, J., Brown, A.C.+, Viscoelastic properties of microgel thin films control fibroblast modes of migration and pro-fibrotic responses. Biomaterials, 2018 (in press).
  2. Nellenbach, K., Guzzetta, N., Brown, A.C.+, Analysis of the structural and mechanical effects of pro-thrombotic agents on neonatal fibrin networks following cardiopulmonary bypass. Journal of Thrombosis and Hemostasis, 2018 (in press).
  3. Sproul, E., Nandi, S., Roosa, C., Shreck, L., Brown, A.C.+, Biomimetic microgels with controllable deformability improve healing outcomes. Advanced Biosystems, doi: 10.1002/adbi.201800042. 2018.
  4. Mihalko, E., Huang, K., Sproul, E., Cheng, K., Brown, A.C.+, Targeted treatment of ischemic and fibrotic complications of myocardial infarction using a dual-delivery microgel therapeutic. ACS Nano, 2018.  doi: 10.1021/acsnano.8b01977.
  5. N Welsch, AC Brown, TH Barker, LA Lyon, Enhancing clot properties through fibrin-specific self-cross-linked PEG side-chain microgels; Colloids and Surfaces B: Biointerfaces 166, 89-97, 2018
  6. J Tang, T Su, K Huang, PU Dinh, Z Wang, A Vandergriff, MT Hensley, J Cores, T Allen, L Taosheng, E Sproul, E Mihalko, L Lobo, L Ruterbories, A Lynch, AC Brown, T Caranasos D Shen, G Stouffer, Z Gu, J Zhang, K Cheng. Targeted repair of heart injury by stem cells fused with platelet nanovesicles. Nature Biomedical Engineering, 2 (1), 17-26, 2018, doi: 10.1038/s41551-017-0182-x.
  7. Joshi, A., Nandi, S., Chester, D., Brown, A.C.+, M. Muller+. Study of poly (N-isopropylacrilamide-co-acrylic acid) (pNIPAM) microgel particle induced deformations of tissue mimicking phantom by ultrasound stimulation. Langmuir, 2017, doi: 10.1021/acs.langmuir.7b02801.
  8. Nandi, S. and Brown, A.C.+ Characterizing cell migration within three-dimensional in vitro wound environments. Journal of Visualized Experiments, 2017, doi:10.1002/ddr.21407.
  9. Nellenbach, K. and Brown, A.C.+ Peptide mimetic drugs for modulating thrombosis and hemostasis.  Drug Development Research, 2017, doi: 10.1002/ddr.21407.
  10. Cao, L., Nicosia, J., Zhang, Y., Bachman, H., Brown, A.C., Holmgren, L, Barker, T.H. Detection of an integrin-binding mechanoswitch within fibronectin during tissue formation and fibrosis. ACS Nano, 2017, doi: 10.1021/acsnano.7b02755
  11. Mihalko E. and Brown, A.C.+ Material strategies for modulating epithelial to mesenchymal transitions. ACS Biomaterials Science and Engineering, 2017, doi: 10.1021/acsbiomaterials.6b00751
  12. Myers, D., Qiu, Y., Fay, M., Tennenbaum, M., Chester, D., Cuadrado, J., Sakurai, Y., Baek, J., Tran, R., Ciciliano, J., Ahn, B., Mannino, R., Bunting, S., Bennett, C., Briones, M., Fernandez-Nieves, A., Smith, M., Brown, A.C., Sulcheck, T., Lam, W.  Single-platelet nanomechanics measured by high-throughput cytometery.  Nature Materials, 2016.  doi: 10.1038/nmat4772
  13. Chester, D., Brown, A.C.+, The role of biophysical properties of provisional matrix proteins in wound repair.  Matrix Biology, 2016.  doi:  10.1016/j.matbio.2016.08.004
  14. Nandi, S., Brown, A.C.+, Platelet-mimetic strategies for modulating the wound environment and inflammatory responses.  Experimental Biology and Medicine, 2016.  doi: 10.1177/153570216647126
  15. Brown, A.C., Hannan, R., Timmins, L., Fernandez, J., Barker, T.H., Guzzetta, N. Fibrin network changes in neonates after cardiopulmonary bypass. Anesthesiology, 2016.**Featured in AAAS Eurekalert! and Hematology Times
  16. Karumbaiaha, L., Enamb, S., Brown, A.C., Saxena, T., Betancura, M., Barker, T.H., Bellamkonda, R. Chondroitin Sulfate Glycosaminoglycan Hydrogels Create Endogenous Niches for Neural Stem Cells. Bioconjugate Chemistry, 2015, 01526 (12), pp 2336–2349
  17. Brown, A.C., Dysart, M.M., Clarke, K.C., Stabenfeldt, S.E., Barker, T.H. Integrin a3b1 binding to fibronectin is dependent on the 9th type III repeat. Journal of Biological Chemistry, 2015, Oct 16;290(42):25534-47. doi: 10.1074/jbc.M115.656702.
  18. Bachman, H.*, Brown, A.C.*+, Clarke, K.*, Dhada, K.*, Douglas, A.*, Hansen, C.*, Herman, E.*, Hyatt, J.*, Kodlekere, P.*, Saxena, S.*, Spears, S.*, Welsch, N.*, Lyon, A.L. Ultrasoft highly deformable microgels. Soft Matter, 2015, 11, 2018-28. doi: 10.1039/c5sm00047e.
  19. Brown, A.C., Baker, S., Douglas, A., Keating, M., Alvarez, M., Botvinick, E., Guthold, M., Barker, T.H. Molecular interference of fibrin’s divalent polymerization mechanism enables modulation of multi-scale material properties. Biomaterials, 2015, 9, 27-36. doi: 10.1016/j.biomaterials.2015.01.010.
  20. Kim, J., Park, Y., Brown, A.C., Lyon, A.L. Observation of ligand-induced dimerization with a bioresponsive hydrogel. RSC Advances, 2014, 4, 65173-65175.
  21. Brown, A.C.*, Stabenfeldt, S.E.*, Ahn, B., Hannan, R., Dhada, K., Herman, E., Stefanelli, V., Guzzetta, N., Alexeev, A., Lam, W.A., Lyon, L.A., Barker, T.H. Ultrasoft microgels displaying emergent platelet-like behaviours. Nature Materials, 2014, 12, 1108-14. doi:10.1038/nmat4066.      **Covered by national and international news outlets including Discover Magazine, Chemical and Engineering News, MRS 360 online, Atlanta Magazine and Times of India
  22. Qui, Y.*, Brown, A.C.*, Myers, D.R., Sakurai, Y., Mannino, R., Tran, R., Ahn, B., Hardy, E., Kee, M., Kumar, S., Bao, G., Barker, T.H., Lam, W.A. Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading and activation. PNAS, 2014, doi: 10.1073/pnas.1322917111.
  23. Bryksin, A.V., Brown, A.C., Baksh, M.M., Finn, M.G., Barker, T.H. Learning from Nature – novel synthetic biology approaches for biomaterials design. Acta Biomater 10, 1761-1769, 2013.
  24. Brown, A.C., Barker, T.H. Fibrin-based biomaterials:  Modulation of macroscopic properties through rational design at the molecular level. Acta Biomater 10, 1502-1514, 2013.
  25. Clarke, K.C., Douglas, A.M., Brown, A.C., Barker, T.H., Lyon, L.A. Colloid-matrix assemblies in regenerative medicine. Curr Opin Colloid Interface Sci 18, 393-405, 2013.
  26. Brown, A.C., Fiore, V.F., Sulchek, T.A., Barker, T.H. Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis associated epithelial to mesenchymal transitions. J Pathol. 229, 25-35, 2013.
  27. Markowski, M.C., Brown, A.C., Barker, T.H. Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues. J Biomed Mater Res A, 100, 2119-27, 2012.
  28. Brown, A.C., Rowe, J., Barker, T.H. Guiding epithelial cell phenotypes with engineered integrin-specific recombinant fibronectin fragments. Tissue Engineering Part A. 17, 139-50, 2011.
  29. Park, E.S., Brown, A.C., DiFeo, M.A., Barker, T.H., Lu, H. Continuously-perfused, non-cross-contaminated microfluidic chamber array for massively parallel cell culture and assay. Lab Chip. 10, 571-80, 2010. **Inside front cover article
  30. Carson, A.E., Barker, T.H. Engineered extracellular matrix variants for directing cell phenotype. Regen Med. 4, 593-600, 2009.

*equal contributions; +corresponding author

Book Chapters and Reports

  1. Chester, D., Marrow, E., Daniele, M., Brown, A.C.+ “Wound Healing and the Host Response in Regenerative Medicine” in Encyclopedia of Biomedical Engineering, Narayan, R., Ed.; Elsevier. (in press).
  2. Sproul, E.P.*, Nandi, S.*, Brown, A.C.+ “Fibrin-based biomaterials for tissue regeneration and repair” in Peptides and proteins as biomaterials for tissue regeneration and repair, Martin, C., Ed.; Elsevier. (in press).
  3. Barker, T.H., Dysart, M.M., Brown, A.C., Fiore, V.F., Russell, A.G., HEI Health Review Committee. “Synergistic effects of particulate matter and substrate stiffness on epithelial-to-mesenchymal transition.”  Res Rep Health Eff Inst. 2014 Nov;(182):3-41.
  4. Stabenfeldt, S.E., Brown, A.C., Barker, T.H. “Engineering ECM complexity into biomaterials for directed differentiation” in Biomaterials as Stem Cell Niches, Roy, K., Ed.; Springer-Verlag: Berlin, Germany 2010.